Individual patterns in aging: monkey's lessons

research on rhesus monkeys suggest that the effects of calorie restriction in nonhuman primates recapitulate many of the physiological, hematological, hormonal, immunological, and biochemical effects produced in rodents [1,2]. Measurments of markers of age-related diseases such as diabetes, cardiovascular disease, and possibly cancer suggest that restricted monkeys are healthier than ad libitum counterparts [3]. Thus, studies in monkeys are very important for identification and characterization of candidate biomarkers of aging. At least one biomarker, the rate of decrease in plasma dehydroepiandrosterone (DHEA), suggests that calorie restricted monkeys may be aging slowly [3]. The intrinsic factors, contributing to decreased stress adaptability in old animals, namely disturbances of the hypothalamic-pituitary-adrenal (HPA) axis, are likely to be responsible, at least in part, for health deterioration in the aged [4,5]. At the same time it is well known that the heterogeneity is crucial feature of the aging process. There are individual peculiarities in vulnerability and resistance to stresses and stress-related pathologies among different persons due to the heterogeneity of the ageing process. It is of great importance to elucidate the individual specificity of age-related changes of the HPA axis in the context of aging of the organism as a whole and the stress-dependent age pathologies. A paper by Goncharova and colleagues from Research Institute of Medical Primatology at Sochi, Russia [6] renders further support to this important issue and indicate a number of highly relevant points that will have to be taken into consideration for a better understanding of mechanisms involved and possible extrapolations to the situation in humans. Their aim was see in which way the differences in the HPA axis function in young (6-8 years) and old (20-27 years) female rhesus monkeys depends on various behavioral types, under basal conditions, as well as under conditions of acute psycho-emotional stress. It has been found that the monkeys with depression-like behavior demonstrate age-related changes in the HPA axis function, accompanied by maximal absolute and relative hypercortisolemia under basal conditions as well as under stress. The authors have also found that young aggressive monkeys, in comparison with young monkeys of other behavior groups, demonstrated the highest plasma levels of DHEA sulfate and the lowest molar ratios between cortisol and DHEA sulfate. No such differences were observed between old aggressive animals and other behavioral groups. The least pronounced age-related changes in the HPA axis have been revealed for the monkeys with average behavior. Goncharova and colleagues …